Use of platelet-rich plasma in aesthetic procedures for skin rejuvenation: review of clinical trials
DOI:
https://doi.org/10.37497/JMRReview.v4i00.78Keywords:
Biostimulation, Healing, Cellular Regeneration, Autologous Therapies and Facial AestheticsAbstract
Background: The skin is the largest organ in the human body, performing essential functions and influencing aesthetic perception and self-esteem. Skin aging motivates the search for treatments that promote rejuvenation, such as the application of retinoids, antioxidants, chemical peels, microneedling, dermal fillers, botulinum toxin, laser therapy and radiofrequency. Platelet-rich plasma (PRP) has emerged as a promising alternative due to its regenerative properties, acting on cell proliferation, collagen synthesis and neovascularization, which improves skin quality and favours tissue regeneration.
Aim: To review the literature on the use of PRP in aesthetic procedures for skin rejuvenation. Method: This exploratory study was conducted using the integrative literature review method, with a focus on synthesizing clinical evidence. The search was carried out in the PUBMED database, using the following search strategy: “platelet rich plasma”[title/abstract] AND skin[title/abstract] AND rejuvenation[title/abstract], with a time cut-off of 5 years.
Results: Initially, 9 studies were identified which met the previously established search strategy. After reading the titles and abstracts, no articles were excluded.
Conclusion: The studies analyzed highlighted varied approaches to the use of PRP and its variations in skin rejuvenation and wound healing. Promising results were observed with self-growing colony extracts, PRP combined with hyaluronic acid and radiofrequency microneedling, while lyophilized and conventional PRP, when used alone, showed limited efficacy in some contexts. This evidence highlights the need for further research to standardize protocols and optimize clinical results.
References
BUCKLEY, D.; PASQUALI, P. Textbook of Primary Care Dermatology. [s.l.] Springer Nature, 2021.
CHAN, G. K. L. et al. An Optimized Extract, Named Self-Growth Colony, from Platelet-Rich Plasma Shows Robust Skin Rejuvenation and Anti-Ageing Properties: A Novel Technology in Development of Cosmetics. Skin Pharmacology and Physiology, v. 34, n. 2, p. 74–85, 2021.
CHEN, S. X. et al. Review of Lasers and Energy-Based Devices for Skin Rejuvenation and Scar Treatment With Histologic Correlations. Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.], v. 48, n. 4, p. 441–448, 1 abr. 2022.
DA SILVA, L. Q. et al. The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial. Archives of Dermatological Research, v. 313, n. 10, p. 863–871, dez. 2021.
GAWDAT, H. et al. Comparison of the efficacy of Fractional Radiofrequency Microneedling alone and in combination with platelet-rich plasma in neck rejuvenation: a clinical and optical coherence tomography study. Journal of Cosmetic Dermatology, v. 21, n. 5, p. 2038–2045, maio 2022.
GRIFFITHS, T. W.; WATSON, R. E. B.; LANGTON, A. K. Skin ageing and topical rejuvenation strategies. The British Journal of Dermatology, v. 189, n. Suppl 1, p. i17–i23, 30 out. 2023.
HASSAN, S. A. et al. Evaluating the Efficacy of Combined Platelet-Rich Plasma and Microneedling for Aesthetic Rejuvenation of the Periorbital Area: A Randomized, Blinded Cohort Study. Journal of Cosmetic Dermatology, v. 24, n. 2, p. e16717, fev. 2025.
HERSANT, B. et al. Synergistic Effects of Autologous Platelet-Rich Plasma and Hyaluronic Acid Injections on Facial Skin Rejuvenation. Aesthetic Surgery Journal, v. 41, n. 7, p. NP854–NP865, 14 jun. 2021.
HUANG, C.-C.; THONG, H.-Y. Rapid Wound Healing and Acne Scar Improvement After Ablative Fractional Carbon Dioxide Laser Treatment Combined with the Application of Platelet-Lyophilized Treatment (PLT). Clinical, Cosmetic and Investigational Dermatology, v. 14, p. 715–721, 2021.
HUMPHREY, S. et al. Defining Skin Quality: Clinical Relevance, Terminology, and Assessment. Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.], v. 47, n. 7, p. 974–981, 1 jul. 2021.
KOUROSH, A. S. et al. Platelet-Rich Plasma: Advances and Controversies in Hair Restoration and Skin Rejuvenation. Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.], v. 50, n. 5, p. 446–452, 1 maio 2024.
PHOEBE, L. K. W. et al. Use of platelet rich plasma for skin rejuvenation. Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), v. 30, n. 4, p. e13714, abr. 2024.
PINCELLI, T. et al. A Pilot, Single-Blind, Randomized Controlled Study Evaluating the Use of Platelet-Rich Plasma for Hand Skin Rejuvenation. Plastic and Reconstructive Surgery, v. 154, n. 4, p. 727–734, 1 out. 2024.
SOUZA, M. T. DE; SILVA, M. D. DA; CARVALHO, R. DE. Revisão integrativa: o que é e como fazer. einstein (São Paulo), v. 8, p. 102–106, mar. 2010.
SWIFT, A. et al. The Facial Aging Process From the “Inside Out”. Aesthetic Surgery Journal, v. 41, n. 10, p. 1107–1119, 14 set. 2021.
TEJERO GARCÍA, P. et al. Photothermal Biostimulation of Platelet-Rich Plasma Improves Hand Rejuvenation Clinical Outcome: A Pilot Study. Photobiomodulation, Photomedicine, and Laser Surgery, v. 42, n. 7, p. 473–479, jun. 2024.
TSAI, Y.-W. et al. Platelet-Rich Plasma Versus Platelet-Poor Plasma for Treating Facial Photoaging: a Double-Blind Randomized Controlled Splitting Face Study. Aesthetic Plastic Surgery, v. 48, n. 11, p. 2162–2170, jun. 2024.
VASSÃO, P. G. et al. Radiofrequency and skin rejuvenation: a systematic review. Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology, v. 24, n. 1–5, p. 9–21, 4 jul. 2022.
VLADULESCU, D. et al. Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action. Biomedicines, v. 12, n. 1, p. 7, 19 dez. 2023.
WHITE, C. et al. Platelet-Rich Plasma: A Comprehensive Review of Emerging Applications in Medical and Aesthetic Dermatology. The Journal of Clinical and Aesthetic Dermatology, v. 14, n. 11, p. 44–57, nov. 2021.
YI, K.-H. et al. Skin boosters: Definitions and varied classifications. Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), v. 30, n. 3, p. e13627, mar. 2024.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
O(s) autor(es) autoriza(m) a publicação do texto na da revista;
O(s) autor(es) garantem que a contribuição é original e inédita e que não está em processo de avaliação em outra(s) revista(s);
A revista não se responsabiliza pelas opiniões, idéias e conceitos emitidos nos textos, por serem de inteira responsabilidade de seu(s) autor(es);
É reservado aos editores o direito de proceder a ajustes textuais e de adequação às normas da publicação.
Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado (Veja O Efeito do Acesso Livre) em http://opcit.eprints.org/oacitation-biblio.html
