Epidemiological profile of congenital malformations identified in the Gynecology and Obstetrics service of a University Hospital
DOI:
https://doi.org/10.37497/JMRReview.v2i1.44Keywords:
Malformations, Epidemiology, Obstetrics, GynecologyAbstract
Background: Congenital malformations are defects in the development of organs and body regions present from birth. Genetic and environmental factors can cause malformations, with some phenotypic associations sharing common etiological mechanisms. Understanding the epidemiological profile of malformations is essential for prevention campaigns and systematic care.
Aim: To identify the epidemiological profile of congenital malformations diagnosed in the Gynecology and Obstetrics Department of a University Hospital located in the city of Bragança Paulista – SP, Brazil.
Method: This is a retrospective, descriptive, and quantitative study that includes internal notifications of congenital malformations identified in the fetuses of pregnant women treated at the Gynecology and Obstetrics Service of the Hospital Universitário São Francisco na Providência de Deus – HUSF.
Results: The sample of this study consisted of 95 malformation notifications, 21 in 2017 (22.11%), 10 in 2018 (10.53%), 10 in 2019 (10.53%), 13 in 2020 (13.69%), 12 in 2021 (12.63%), 14 in 2022 (14.73%) and 15 in 2023 (15.78%). The frequency of malformations in 2017 was significantly higher than that observed in the rest of the years evaluated (p = 0.04). The average maternal age during the studied period was 29.3 ± 7.4 years. The most commonly identified malformations were those occurring in structures of the central nervous system, as well as those identified in the cardiovascular system.
Conclusion: In our study, the most frequent malformations were associated with structures of the central nervous system, as well as cardiovascular structures. Despite the fact that this specific survey did not evaluate risk factors in pregnant women, it is noteworthy that contact with agricultural products may be associated with malformations, suggesting the need to create campaigns to inform pregnant women about the dangers of exposure to these compounds.
References
ANTONOV, O. V.; SHIRINSKIĬ, V. A.; ANTONOVA, I. V. Hygienic risk factors of congenital malformations. Gigiena I Sanitariia, n. 5, p. 20–22, 2008.
CIFUENTES, L. et al. Congenital malformations: a model predictive based on risk factors. Revista Medica De Chile, v. 117, n. 6, p. 611–617, jun. 1989.
CORSELLO, G.; GIUFFRÈ, M. Congenital malformations. The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, v. 25 Suppl 1, p. 25–29, abr. 2012. DOI: https://doi.org/10.3109/14767058.2012.664943
CREMONESE, C. et al. Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil. International Journal of Occupational Medicine and Environmental Health, v. 27, n. 3, p. 474–486, jun. 2014. DOI: https://doi.org/10.2478/s13382-014-0269-5
EMMS, A. et al. Next Generation Sequencing after Invasive Prenatal Testing in Fetuses with Congenital Malformations: Prenatal or Neonatal Investigation. Genes, v. 13, n. 9, p. 1517, 24 ago. 2022. DOI: https://doi.org/10.3390/genes13091517
IBAÑEZ, H. C. et al. Spatial trends in congenital malformations and stream water chemistry in Southern Brazil. The Science of the Total Environment, v. 650, n. Pt 1, p. 1278–1291, 10 fev. 2019. DOI: https://doi.org/10.1016/j.scitotenv.2018.09.061
IMPELLIZZERI, P. et al. Pathogenesis of Congenital Malformations: Possible Role of Oxidative Stress. American Journal of Perinatology, v. 39, n. 8, p. 816–823, jun. 2022. DOI: https://doi.org/10.1055/s-0040-1721081
PAULI, R. M.; REISER, C. A. Wisconsin Stillbirth Service Program: II. Analysis of diagnoses and diagnostic categories in the first 1,000 referrals. American Journal of Medical Genetics, v. 50, n. 2, p. 135–153, 1 abr. 1994. DOI: https://doi.org/10.1002/ajmg.1320500205
SHEPARD, T. H.; FANTEL, A. G.; FITZSIMMONS, J. Congenital defect rates among spontaneous abortuses: twenty years of monitoring. Teratology, v. 39, n. 4, p. 325–331, abr. 1989. DOI: https://doi.org/10.1002/tera.1420390404
TOUFAILY, M. H. et al. Causes of Congenital Malformations. Birth Defects Research, v. 110, n. 2, p. 87–91, 2018. DOI: https://doi.org/10.1002/bdr2.1105
ZHANG, Y.-X. et al. Genetic analysis of first-trimester miscarriages with a combination of cytogenetic karyotyping, microsatellite genotyping and arrayCGH. Clinical Genetics, v. 75, n. 2, p. 133–140, fev. 2009. DOI: https://doi.org/10.1111/j.1399-0004.2008.01131.x
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
O(s) autor(es) autoriza(m) a publicação do texto na da revista;
O(s) autor(es) garantem que a contribuição é original e inédita e que não está em processo de avaliação em outra(s) revista(s);
A revista não se responsabiliza pelas opiniões, idéias e conceitos emitidos nos textos, por serem de inteira responsabilidade de seu(s) autor(es);
É reservado aos editores o direito de proceder a ajustes textuais e de adequação às normas da publicação.
Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado (Veja O Efeito do Acesso Livre) em http://opcit.eprints.org/oacitation-biblio.html
