Abstract
Background: Pneumonia is a common acute respiratory infection that affects the alveoli and the distal bronchial tree of the lungs. The disease is broadly divided into community-acquired pneumonia (CAP) or hospital-acquired pneumonia (HAP). CAP is defined as pneumonia occurring in a patient with no recent exposure to healthcare, and covers an extremely variable clinical spectrum, ranging from patients with healthy appearance to necrotizing or multilobar disease with septic shock. Pneumonia carries the highest mortality of any infectious disease, and children under five are one of the most borne by the PAC, with cases accounting for 107.7 episodes per 1,000 children.
Aim: Through a literature review, to evaluate the evidence on the treatment of pneumonia in children, with a CAP approach. Method: This is an exploratory study, based on the method of integrative literature review. The database chosen for the selection of studies was PUBMED, using the following search strategy: pneumonia[title] AND treatment[title] AND (children[title] OR pediatrics[title]). Any paper that discussed the proposed topic was initially included in the sample. Results: A total of 396 papers that responded to previously established strategy were identified. After reading the titles and abstracts, 32 scientific articles were included in this review.
Conclusion: The main finding of this review was that the decrease in time and dosage of treatments with beta-lactam drugs (mainly amoxicillin) were effective and safe for the treatment of CAP in children. In addition, a shorter course of amoxicillin improves adherence to therapy, is inexpensive, and puts less pressure on antimicrobial resistance. However, the severity of the disease, the treatment site, and previously used antibiotics must be taken into account before applying the protocols.
References
ALIBERTI, S. et al. Multidrug-resistant pathogens in hospitalised patients coming from the community with pneumonia: a European perspective. Thorax, v. 68, n. 11, p. 997–999, nov. 2013.
BARTLETT, J. G.; MUNDY, L. M. Community-acquired pneumonia. The New England Journal of Medicine, v. 333, n. 24, p. 1618–1624, 14 dez. 1995.
BATAEV, S. M. et al. The first experience of the use of hydro-surgical technologies in the treatment of children with pulmatic-pleural complications of destructive pneumonia. Khirurgiia, n. 7, p. 15–23, 2019.
BENEDICTIS, F. M. DE et al. Complicated pneumonia in children. The Lancet, v. 396, n. 10253, p. 786–798, 12 set. 2020.
BHUIYAN, M. U. et al. Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children. BMC Pulmonary Medicine, v. 19, n. 1, p. 71, 2 abr. 2019.
BIELICKI, J. A. et al. Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial. JAMA, v. 326, n. 17, p. 1713–1724, 2 nov. 2021.
CHALMERS, J. D. et al. Risk factors for complicated parapneumonic effusion and empyema on presentation to hospital with community-acquired pneumonia. Thorax, v. 64, n. 7, p. 592–597, 1 jul. 2009.
CHALMERS, J. D. et al. Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis. Thorax, v. 65, n. 10, p. 878–883, out. 2010.
CILLÓNIZ, C. et al. Microbial aetiology of community-acquired pneumonia and its relation to severity. Thorax, v. 66, n. 4, p. 340–346, abr. 2011.
FALGUERA, M. et al. Predictive factors, microbiology and outcome of patients with parapneumonic effusion. The European Respiratory Journal, v. 38, n. 5, p. 1173–1179, nov. 2011.
JAIN, S. et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. The New England Journal of Medicine, v. 373, n. 5, p. 415–427, 30 jul. 2015.
KARHU, J. et al. Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, v. 59, n. 1, p. 62–70, 1 jul. 2014.
KOHNS VASCONCELOS, M. et al. Detection of mostly viral pathogens and high proportion of antibiotic treatment initiation in hospitalised children with community-acquired pneumonia in Switzerland - baseline findings from the first two years of the KIDS-STEP trial. Swiss Medical Weekly, v. 153, p. 40040, 20 fev. 2023.
LAMPING, D. L. et al. The community-acquired pneumonia symptom questionnaire: a new, patient-based outcome measure to evaluate symptoms in patients with community-acquired pneumonia. Chest, v. 122, n. 3, p. 920–929, set. 2002.
METLAY, J. P. et al. Measuring symptomatic and functional recovery in patients with community-acquired pneumonia. Journal of General Internal Medicine, v. 12, n. 7, p. 423–430, jul. 1997.
METLAY, J. P. et al. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. American Journal of Respiratory and Critical Care Medicine, v. 200, n. 7, p. e45–e67, 1 out. 2019.
MOBERLEY, S. et al. Vaccines for preventing pneumococcal infection in adults. The Cochrane Database of Systematic Reviews, v. 2013, n. 1, p. CD000422, 31 jan. 2013.
MUSHER, D. M.; THORNER, A. R. Community-acquired pneumonia. The New England Journal of Medicine, v. 371, n. 17, p. 1619–1628, 23 out. 2014.
MVALO, T. et al. Antibiotic treatment failure in children aged 1 to 59 months with World Health Organization-defined severe pneumonia in Malawi: A CPAP IMPACT trial secondary analysis. PloS One, v. 17, n. 12, p. e0278938, 2022.
NASCIMENTO-CARVALHO, C. M. Community-acquired pneumonia among children: the latest evidence for an updated management. Jornal de pediatria, v. 96, p. 29–38, 2020.
PETTIGREW, M. M. et al. Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia. mBio, v. 13, n. 2, p. e0019522, 26 abr. 2022.
PRINA, E.; RANZANI, O. T.; TORRES, A. Community-acquired pneumonia. Lancet (London, England), v. 386, n. 9998, p. 1097–1108, 12 set. 2015.
QIAO, M. et al. [Acupuncture at Sifeng (EX-UE 10) as adjuvant treatment for pneumonia of phlegm-heat blocking lung type in children: a randomized controlled trial]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, v. 40, n. 10, p. 1076–1080, 12 out. 2020.
RERKSUPPAPHOL, L.; RERKSUPPAPHOL, S. Efficacy of Adjunctive Zinc in Improving the Treatment Outcomes in Hospitalized Children with Pneumonia: A Randomized Controlled Trial. Journal of Tropical Pediatrics, v. 66, n. 4, p. 419–427, 1 ago. 2020.
RIDER, A. C.; FRAZEE, B. W. Community-Acquired Pneumonia. Emergency Medicine Clinics of North America, v. 36, n. 4, p. 665–683, nov. 2018.
SADRUDDIN, S. et al. Comparison of 3 Days Amoxicillin Versus 5 Days Co-Trimoxazole for Treatment of Fast-breathing Pneumonia by Community Health Workers in Children Aged 2-59 Months in Pakistan: A Cluster-randomized Trial. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, v. 69, n. 3, p. 397–404, 18 jul. 2019.
SHINDO, Y. et al. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. American Journal of Respiratory and Critical Care Medicine, v. 188, n. 8, p. 985–995, 15 out. 2013.
TORRES, A. et al. Pneumonia. Nature Reviews Disease Primers, v. 7, n. 1, p. 1–28, 8 abr. 2021.
VOS, T. et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, v. 396, n. 10258, p. 1204–1222, 17 out. 2020.
WU, X. et al. Incidence of respiratory viral infections detected by PCR and real-time PCR in adult patients with community-acquired pneumonia: a meta-analysis. Respiration; International Review of Thoracic Diseases, v. 89, n. 4, p. 343–352, 2015.
YUN, K. W. et al. Community-acquired pneumonia in children: myths and facts. American journal of perinatology, v. 36, n. S 02, p. S54–S57, 2019.
ZHOU, F. et al. Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network. The European Respiratory Journal, v. 54, n. 2, p. 1802406, ago. 2019.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Amanda Rocha Moreno, Priscilla Guerra Moura